Which of the following can increase the risk of developing an asbestos-related disease?

Prolonged exposure to high doses of asbestos is the most significant factor that increases the risk of developing asbestos-related diseases. Asbestos is a group of naturally occurring silicate minerals that were widely used in construction, insulation, and other industries due to their fire-resistant properties. When asbestos fibers are inhaled or ingested over an extended period, they can cause serious health conditions, including asbestosis, lung cancer, and mesothelioma.

The risk of developing these diseases correlates strongly with both the duration and intensity of exposure. High doses not only mean more fibers entering the body but also increase the likelihood of cellular damage that leads to disease over time. Therefore, those who have prolonged occupational exposure in environments where asbestos is present are at a much higher risk compared to individuals with limited or no exposure.

In contrast, other options present lower risks. Working in a clean environment generally involves less exposure to harmful substances, including asbestos. Short-term exposure, while not without risk, is less likely to lead to disease when compared to long-term, high-dose exposure. Regular health screenings can help in early detection and intervention for diseases but do not increase the risk of developing those diseases. Hence, they play a preventive role rather than a causative one.